Keith Fenrich, PhD

Keith

 fenrich@ualberta.ca

Positions held/Education

2013-present: Post-Doctoral Fellow, labs of Drs. Karim Fouad and David Bennett, University of Alberta, Edmonton AB, Canada

2010-2013: Post-Doctoral Fellow, lab of Dr. Genevieve Rougon, IBDML research institutes, Marseille, France.

2003-2009: PhD (Physiology), supervised by Dr. P.Ken Rose. Department of Physiology, Queen’s University, Kingston ON, Canada

2001-2003: Undergraduate research assistant in the laboratory of Dr. Vivian K. Mushahwar, University of Alberta

1999-2003: BSc with specialization in Pharmacology, University of Alberta, Edmonton AB, Canada  

Grants and Fellowships

Canadian Institute of Health Research (CIHR) Postdoctoral Fellowship, Canada. Commissural interneurons in locomotion and spasticity after spinal cord injury. 2013-2014. $67,000 stipend; $8400 research allowance.

Alberta Innovates Health Solutions (AIHS) Postgraduate Fellowship, Canada. Commissural interneurons in locomotion and spasticity after spinal cord injury. 2013-2016. $150,000 stipend; $15,000 research allowance.

Rougon G and Fenrich K.K. Chronic in vivo two-photon imaging of fluorescent transgenic mice with EAE: a study of macrophage recruitment, cell-cell interactions, and the roles of VEGF. Fondation pour l’Aide à la Recherche sur the Sclérose En Plaques (ARSEP), France. 2011-2013 (1.5 years). €42 500.

Fondation pour l’Aide à la Recherche sur the Sclérose En Plaques (ARSEP) Fellowship, France. Development of a two-photon in vivo microscopy technique for the chronic visualization of axonal-oligodendroglial interactions in the mouse spinal cord. 2010-2013 (2.5 years). €125,500.

Rougon G and Fenrich K.K. Chronic visualization of diseased axon behaviour and interactions in the mouse spinal cord using two-photon in vivo microscopy and evaluation of VEGF targets and effects. Fondation pour l’Aide à la Recherche sur the Sclérose En Plaques (ARSEP), France. 2010-2011. €40 000.

Ontario Graduate Scholarship (OGS), Government of Ontario Ministry of Training, Colleges and Universities, Canada. 2008-2009. $15,000.

Dr. Robert John Wilson Fellowship, Queen’s University, Canada. 2007-2009. $20,000 (accepted from September 2007 to May 2008 only)

Ontario Graduate Scholarship (OGS), Government of Ontario Ministry of Training, Colleges and Universities, Canada. 2006-2007. $15,000.

Dr. Robert John Wilson Fellowship, Queen’s University, Canada. 2005-2007. $20,000 (accepted for the 2005-2006 academic year only)

Trevor C Holland Fellowship, Queen's University, Canada.  2004-2005. $10,000.

Queen’s Graduate Award, Queen’s University, Canada.  2003-2004. $6,000.

Alexander Rutherford Scholarship, Alberta Scholarship Programs, Canada.  September 1999. $2,500.

Honors / Awards

Canadian Spinal Cord Injury Meeting - Award for Best Presentation 2013. Canadian Spinal Cord Injury Meeting, Halifax, Canada. $300. 

ARSEP Young Investigator Travel Award. 2012. Fondation pour l’Aide à la Recherche sur the Sclérose En Plaques (ARSEP), France. €300.

Brain Star Award (national competition). 2009. Canadian Institutes of Health Research Institute of Neurosciences, Mental Health and Addiction (CIHR INMHA), Canada. $1000.

The Abrahams Prize in Physiology. 2009. Queen’s University, Canada. $1000.

The Harry Abramsky Charitable Foundation Fund Travel Award. 2009. Queen’s University, Canada. $1000

CAN-ACN Young Neuroscientist Award (national competition). 2008. Canadian Association for Neuroscience / Association Canadienne des Neurosciences. $300.

Neuroscience Research Day Abstract Award, 2006. Center for Neuroscience Studies, Queen’s University, Canada. $200.

Publications

Paveliev, M., Fenrich, K.K., Kislin, M., Kulesskaya, N., Kuja-Panula, J., Kajander, T., Määttänen, A., Kari, E., Mugantseva, E., Ahonen-Bishopp, A., Khiroug, L., Ihalainen, P., Reikkola, M.L., Peltonen, J., Rougon, G., Rauvala, H. HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by chondroitin sulfate proteoglycans. Sci. Reports (Under review; SREP-16-11686).

Wei, D., Hurd, C., Galleguillos, D., Singh, J., Fenrich K.K., Webber, C., Sipione, S., Fouad, K. Inhibiting cortical PKA activity in spinal cord injured rats allows for enhanced corticospinal tract plasticity and rehabilitative training efficacy via EPAC. Exp. Neurol. (Revisions submitted).

Li, Y., Lucas-Osma, A., Bandet, M.V., Ma, Y., Stephens, M.J., Vavrek, R., Sanelli, L., Fenrich, K.K., Winship, I.R., Fouad, K., Bennett, D.J. Chronic hypoxia mediated by trace amines after spinal cord injury. Nature Medicine (Revisions submitted: Ms. Ref. No. NMED-A78214).

Fenrich, K.K., May, Z., Torres-Espín, A., Forero, J., Bennett, D.J., Fouad, K. Single pellet grasping following cervical spinal cord injury in adult rat using automated ad libitum full-time training robot. (2016). Behav Brain Res, 299:59-71. doi: 10.1016/j.bbr.2015.11.020.

Maratta, R., Fenrich, K.K., Zhao, E.Y., Neuber-Hess, M.S., Rose, P.K. Distribution and density of contacts from noradrenergic and serotonergic boutons on the dendrites of neck flexor motoneurons in the adult cat. (2015) J. Comp Neurol.523(11):1701-1716

Fenrich, K.K., May, Z., Hurd, C., Boychuk, C.E., Kowalczewski, J., Bennett, D.J., Whishaw, I.Q., Fouad, K. Improved single pellet grasping using automated ad libitum full-time training robot. (2015) Behav Brain Res. 281:137-148.(Corresponding author).

Fenrich, K.K., *Zhao, E.Y., Wei, Y., Garg, A., Rose, P.K. Isolating specific cell and tissue compartments from 3D image stacks for quantitative regional distribution analysis using novel high-throughput algorithms. (2014) Journal of Neuroscience Methods – 226(2014):42-56. (Corresponding author; *co-lead author).

Fenrich, K.K., Weber, P., Rougon, G., Debarbieux, F. Implanting glass spinal cord windows in adult mice with experimental autoimmune encephalomyelitis. (2013) J. Vis. Exp. (82), e50826, doi:10.3791/50826 (2013). (Corresponding author).

Fenrich, K.K., Weber, P., Rougon, G., Debarbieux, F. Infiltrating but not resident macrophages cause axon collapse and inhibit growth after spinal cord injury. (2013) J Physiol. 591(19):4895-4902 (Cover, corresponding author).

Montague, S.J., Fenrich, K.K., Mayer-Macaulay, C., Maratta, R., Neuber-Hess, M.S., Rose, P.K. Non-uniform distribution of contacts from noradrenergic and serotonergic boutons on the dendrites of cat splenius motoneurons. (2013) J. Comp Neurol. 521(3):638-656.

Fenrich, K.K., Weber, P., Hocine, M., Zalc, M., Rougon, G., Debarbieux, F. Long-term in vivo imaging of normal and pathological mouse spinal cord with sub-cellular resolution using implanted glass windows. (2012) J. Physiol. 590(16):3665-3675. (Corresponding author).

Fenrich, K.K. and Rose, P.K. Axons with Highly Branched Terminal Regions Successfully Regenerate across Spinal Midline Transections in the Adult Cat. (2011) J. Comp. Neurol. 519(16):3240-3258. (Corresponding author).

Fenrich, K.K. and Rose, P.K. Spinal Interneuron Axons Spontaneously Regenerate following Spinal Cord Injury in the Adult Feline. (2009) J. Neurosci. 29(39):12145-12148 (Editorial feature, corresponding author).

Fenrich, K.K., Skelton, N., MacDermid, V., Meehan, C.F., Armstrong, S., Neuber-Hess, M.S., and Rose, P.K. Axonal regeneration and development of de novo axons from distal dendrites of adult feline commissural interneurons after proximal axotomy. (2007) J. Comp. Neurol. 502(6):1079-97. (Corresponding author).

Brunt, K.R., Fenrich, K.K., Kiani, G., Tse, M.Y., Pang, S.C., Ward, C.A., and Melo, L.G. Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional co-dependence between HO-1 and AKT. (2006)  Arterioscler. Thromb. Vasc. Biol. 26(9): 2027-34.

 

Fenrich, K., and Gordon, T.  Axonal Regeneration in the Peripheral and Central Nervous Systems: Current Issues and Advances. (2004)  Can. J. Neurol. Sci. 31(2): 142-156.